5-amino-1mq safety toxicity study Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice Nicotinamide N-Methyltransferase in Cardiovascular Diseases:

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The safety profile is very favorable , no effect on insulin, IGF-1, cortisol, growth hormones

The theory is that gradual dose reduction gives the body time to recalibrate appetite and metabolic signaling, rather than experiencing a sudden return to pre-treatment hunger levels

Inhibition of lipid synthase activity: AOD 9604 reduces the activities of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreases de novo synthesis of fatty acids

In preclinical models this combination showed an additive effect