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People with a compromised immune system If you have a weakened immune system whether its because of chemotherapy, organ transplantation, biologics or HIV you face a double challenge: Not only are you more vulnerable to severe illness if you get the flu, but your immune response to the vaccine may be blunted

doi: 10.1016/j.heliyon.2024.e24662 33 WilkinsALKazminDNapolitaniGClutterbuckEAPulendranBSiegristCet al

If a pregnant patient has a documented deficiency of one or more B vitamins or a condition like hyperemesis that prevents oral intake, the benefits of correcting the deficiency (preventing serious maternal and fetal complications) outweigh any minimal risk from the injection

It interferes with the absorption of the B12intrinsic factor complex in the terminal ileum

During hot months, the body loses a lot of water through sweat