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Despite varying phenotypes across patient-derived iPSC models of PD, their application in the pursuit of biomarkers or novel therapeutic compounds is still ongoing

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Dalton PD, Dieter MZ, Yang Y, Shertzer HG, Nebert DW: Knockout of the mouse glutamate cysteine ligase catalytic subunit ( Gclc ) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozyogous

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Biotechnology Letters, 41 , 471481