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Specifically, IKE boasts a solubility that is three times higher than erastin, and it exhibits a remarkable 50-fold reduction in the Lethal Concentration 50 (LC50) for tumor cells, indicating a significantly enhanced antitumor potency ( DPI2, a FIN (ferroptosis-inducing compound), which does not inhibit GPx4 activity but specifically inhibits SLC7A11 expression, consumed 90% of the GSH in BjeLR cells compared to the untreated group

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This regulation promotes BRCA progression by enhancing cell proliferation through cross-talk with signaling pathways like RAS-RAF-MEK and PI3K-AKT, independent of mTORC1