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Growing evidence indicate that surgical interventions and general anesthesia can disrupt gut microbiota homeostasis, compromise both intestinal mucosal barrier integrity and BBB function, thereby facilitating bacterial translocation and metabolite dissemination into systemic circulation (Minerbi and Shen, 2022)

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Int J Mol Sci 21(2):569 Levine F, Ogunwobi OO (2021) Targeting PVT1 Exon 9 re-expresses Claudin 4 protein and inhibits migration by Claudin-low triple negative breast cancer cells

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Sulforaphane-rich broccoli sprouts , which activate the Nrf2 pathway and stimulate production of the body's own detoxification enzymes 9