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Fatigue Reduction : B12 injections are particularly effective in combating fatigue, a common issue for patients on calorie-restricted diets

However, due to small sample sizes and lack of comparative studies, extensive research needs to be conducted before the widespread introduction of these treatments (Meisel et al., 2019)

There was no evidence of mutagenic potential when dihydroergotamine mesylate was tested in the presence or absence of metabolic activation in two gene mutation assays (the Ames test and the in vitro mammalian Chinese hamster V79/HGPRT assay) and in an assay for DNA damage (the rat hepatocyte unscheduled DNA synthesis test)

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