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In many PCS patients, no clear pathophysiological substrate is found on usual (blood) examination

Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production

Figure 2 In summary, given the major influence of the gut and its microbiota on the overall immune/inflammatory system and on neuroinflammation, and considering the importance of the MGB axis, one can foresee that well designed diets, complements or treatments aiming at reducing dysbiosis and gut inflammation may have a beneficial effect on different PAIS

This does suggest a reduced need for vitamin C

melatonin activates Nrf2 to inhibit oxidative stress/ferroptosis in hypoxic/reoxygenated tubular cells, preventing AKI ( Figure 4