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Yu P, et al

In this study a genetic selection led to the identification of a bacterial mutant in glutathione synthase that exhibited reduced virulence gene expression and was attenuated 150-fold in mice

Sepiapterin is a stable precursor in the salvage pathway of BH 4 biosynthesis, which converts sepiapterin to BH 4 via the activities of sepiapterin reductase and DHFR (Figure 8)