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The results show an inflammatory response associated with oxidative stress, local gliosis, and increased levels of IL-1, TNF-1, iNOS, reactive oxygen species, lipid peroxidation, and nitric oxide

NO released from the vascular endothelium is also an antioxidative factor that neutralizes O 2 [76] and impairment of NO synthesis marks the onset of endothelial dysfunction that is mainly mediated by the endothelial NO synthase (eNOS) uncoupling mechanism [77]

systematic reviews indicate that short-term oral contraceptive use does not significantly alter the gut microbiota in PCOS patients (109)

Some studies indicate that the risk is also due to higher homocysteine levels[ref], while other studies show that it may be due to the methylation of certain genes.[ref] Meta-analyses showed that the MTHFR C677T variant increased the risk of migraines with aura for all population ancestry groups