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Hereditary cerebral folate malabsorption is a secondary cause of cerebral folate malabsorption, with nearly half of the patients having a consanguineous parent and a mortality rate of 40%, with women being more susceptible than men [114]

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Across the patients we serve, an unexplained iron deficiency in an older adult with no bleeding source is one of the most reliable prompts to look at B12 and intrinsic factor antibodies

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The dose escalation design tested different starting doses (2 mg vs 4 mg) to evaluate tolerability