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Excess levels of catecholamines, such as epinephrine, norepinephrine, and dopamine, can result in dangerous hypertension events

& Felder, C

Her pain often resists treatment and becomes disabling, yet doctors still havent identified the cause

This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression

It is evident that the blood-brain barrier is crossed by a passive flux of oxysterols, but not of cholesterol per se, as a result of their higher polarity and permissive chemical structures and following their concentration gradients