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Early detection and interventions targeting the cGAS-STING signaling are important for reducing the medical burden on individuals and healthcare systems

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Mitochondrial-mediated ROS cause oxidative damage to cellular structures, particularly mitochondrial DNA, somatic mutations, genome instability, inactivation of tumor suppressor genes, alterations in metabolic and signaling pathways with simultaneous activation of compensatory antioxidant mechanisms, all of which contribute to cell transformation and thus promote various types of cancer [42]

Identification of PAD2 as a glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis