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While progesterone is an important component of HRT for many women, some individuals are more sensitive to certain forms of progesterone or synthetic progestins

Proper technique maximizes the absorption that makes timing differences meaningful

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Cardiovascular symptoms to report within 24 hours : sustained resting heart rate above 100 bpm, home blood pressure readings above 150/95 mmHg on two consecutive measurements, dizziness on standing (suggesting orthostatic instability), or new-onset headache that differs from the patient's typical pattern