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Indeed, ouabain induced multiple rejuvenation hallmarks shared by HPB, such as downregulation of Cdkn1a and Vcam1 , a vascular cell adhesion molecule shown to modulate neuroinflammation and impair the cognitive function of old mice 129

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These phosphorylation events (PTMs) destabilize the mitochondrial outer membrane, promote mitochondrial outer membrane permeabilization (MOMP), cytochrome c release and caspase activation, and directly reduce mitochondrial membrane potential (m) and ATP generation (57)