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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

In addition, A phased approach to microbiometargeted therapy in ICU patients is proposed

[27] Septic-shock and ARDS protocols use 0.1 mg/kg daily up to ten days, whereas perioperative antiemetic regimens commonly employ a single 4-10 mg IV bolus at induction, capitalizing on rapid onset ( 95 % potency retention for dexamethasone sodium phosphate vials stored 20-25 C and shielded from intense light for 91 days

C.BkA.JessenN.et al (2020)

Maher JJ