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If APAP injection is able to stimulates fatty acids accretion per se 4 , the overexpression of PGC-1 boosts the expression of genes involved in de novo lipogenesis and triglycerides synthesis, thus contributing to the impairment of normal liver functions

Its also the single most protective antioxidant produced by the body and is therefore the most important for protecting cells against oxidative stress from dietary and environmental free radicals as well as those resulting from normal metabolic processes

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