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Moreover, RNA-sequencing of resident GC B cells showed that glycolysis-related HIF-1a target genes, originally increased in GC B cells propagated in vitro , were actually low in cells taken directly ex vivo

Furthermore, the Bax/Bcl-2 ratio was significantly elevated in the ICH group, but decreased substantially following EW treatment, shifting the balance toward an anti-apoptotic phenotype

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Therefore, the efficacy of ICIs therapy for advanced NSCLC patients could be assessed in advance