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35 Dihydroartemisinin induced ferroptosis by promoting the formation of phosphatidylethanolamine-binding protein 1/15-lipoxygenases and promoting cell membrane lipid peroxidation, thereby exerting anti-HCC activity

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(2014) investigated 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives for their ability to selectively inhibit cyclooxygenase-2 (COX-2), an enzyme linked to inflammation The results showed that both the position of the SO 2 Me group (a known COX-2-targeting feature) and the type of other substituents played an important role in determining how well the compounds worked and how selective they were for COX-2

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