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2 The pathogenesis of rheumatoid arthritis RA is initially characterized by persistent activation of cells, leading to autoimmunity in the joints or other affected organs (10)

Soluble factors include the complement, acute-phase proteins, and cytokines [30]

Case presentation A man in his 40s presented with fatigue, imbalance, and numbness and tingling

Thus, the interaction between alcohol-induced stress, HPA axis dysregulation, and neurotrophic factors is critical in understanding the development of depression in individuals with chronic alcohol use

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