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Functional enrichment showed upregulation of ubiquitin-dependent catabolic processes and downregulation of mitotic pathways, supporting altered stress responses and cell cycle disruptions in iron-exposed chondrocytes

Despite its high bioavailability potentially limiting its clinical use, thiamine is still a promising nutraceutical option for cancer treatment [81]

Review precision design of engineered nanomaterials to guide immune systems for disease treatment

With increasing methionine intake, the transsulfuration pathway, which provides a substrate for GSH synthesis, is increased

The sense sequences of si-GPX3 are listed in Additional file 4: Table S4