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Regulatory T cells and immune tolerance

MicroRNA-26a/death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinsons disease

This reduction leads to increased monomethylation at lysine 224 (K224) of PGC-1, inhibiting its interaction with the transcription factor NRF1/2 and subsequently suppressing mitochondrial biogenesis