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Bullous rash reactions including Stevens-Johnson syndrome and Lyells syndrome (toxic epidermal necrolysis), exfoliative dermatitis, erythema multiforme, and anaphylactoid reactions including anaphylactic shock, angioedema, and tongue or laryngeal edema have been reported through the postmarketing surveillance program

33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline

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In a phase 2 trial involving people with obesity, the 12 mg weekly dose of retatrutide resulted in a placebo-adjusted mean weight reduction of 22.1% after 48 weeks of treatment