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Powell-Wiley TM, Poirier P, Burke LE, et al

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The physical barrier function is mainly performed by the corneocytes, while the water permeability barrier is achieved by the lipid matrix

Therefore, combined curcumin and luteolin synergically inhibited colon cancer development by suppressing cell proliferation, necrosis, and migration associated with Notch1 and TGF- pathways