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While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3] [10]

The Modifier 26 claim needs a specific documentation foundation before submission: a signed, dated interpretation report with indication, technique, level-by-level findings, and clinical impression

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