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(121) found that EODF did not show beneficial effects on disease onset or progression in ALS mice with the Cu/Zn SOD gene mutation, and once symptoms appeared, EODF actually accelerated disease progression

further revealed that ferrostatin-1adminstration rescued high-iron diet-induced severe cardiac injury and hypertrophic cardiomyopathy, with molecular features typical of ferroptosis, including reduced GSH levels and increased LPO

Pravalika et al., 2018

Galmarini 2012

Glutathione is involved in many metabolic processes that include scavenging of free radicals and ROS, detoxification of several products such as lipid peroxides and xenobiotics, and it also plays a crucial role in the regeneration of ascorbate and tocopherol-based antioxidants (Yamasoba et al., 1998