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Furthermore, metformin treatment alone was demonstrated to significantly induce cell death in both HCT116 and SW837 cells, although this effect was more pronounced in HCT116 cells, supporting previous studies (63)

Exocytosis of gelatinase and azurophilic granules, regulated by Munc13-4Rab27a, was unaffected by ENDOs when stimulation occurred through plasma membrane receptors, further supporting specificity for endosomal, Munc13-4-dependent mechanisms mediated by STX7

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The Diazinon group showed a slight increase compared to the control group (D.W.), this difference was also statistically significant

Throughout his career, Marcos has led complex organizations across the United States, Latin America, Europe, and Asia, building strong leadership teams and translating strategy into disciplined execution