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(1) Stimulate chondrocytes to synthesize Col-II and proteoglycans, while inhibiting the activities of MMP-13 and ADAMTS-5, and reducing matrix degradation

Fratta Pasini et al., 2021

These findings underscore the importance of NADPH in dealing with oxidative stress especially at times when most or all of the rods have degenerated, thereby exacerbating photo-oxidation due to increase of inflow of oxygen