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Enzyme-cleavable linkers utilize tumor-specific protease activity, such as Cathepsin B, Cathepsin L, or matrix metalloproteinases (MMPs), to release the payload

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Moreover, Nrf2a key regulator of iron homeostasisis robustly activated by BL (Yao et al., 2020a,b), leading to increased production of NAD(P)H-dependent enzymes such as NQO1, suppression of NF-B signaling, and reduction of both -Syn aggregation and oxidative stressmediated neuroinflammatory damage (Lastres-Becker et al., 2016

Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: mechanism of action and potential applications in intestinal disorders

IJPR 18, 13951402