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63,65 NF-B, as a key transcription factor, can lead to the overexpression of various pro-inflammatory genes with sustained activation, further enhancing local inflammation, creating a vicious cycle, and ultimately leading to abnormal follicular development and oocyte dysfunction

These findings may suggest that mitochondrial dysfunction amplifies systemic manifestations through its interplay with non-mitochondrial molecular pathways

Synchronizing exercise and nutrient interventions to the circadian clock might maximize the health-promoting benefits of interventions to prevent and treat metabolic disease [50]

Rashidinejad A, Birch EJ, Everett DW

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