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Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

People with severe kidney disease require more individualized dosing and monitoring because vitamin handling changes in renal impairment

This helps ward off megaloblastic anemia caused by B12 deficiency

Said Vyas: "It's the uncertainty that creates an incredible amount of anxiety in this entire value chain, and therefore you see this kind of a fluctuation, both on the supply side as well as the demand side." This year, Seroka expects cargo volumes to drop through November and December - unlike last year, when companies rushed to import early to avoid possible tariff hikes

When Not to Use: Avoid in cases of hypersensitivity to B vitamins or related compounds