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Due to the evidently good predictivity of the in vivo alkaline comet assay, it seemed worthwhile to also evaluate the in vitro alkaline comet assay regarding its potential to detect mutagenic/carcinogenic NAs, when performed with relevant, metabolically competent mammalian tissue or cell types

Practical expectations should stay realistic

[DOI] [PubMed] [Google Scholar] 103.Skvortsov S., Skvortsova I.I., Tang D.G., Dubrovska A

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On top of that, the production of glutathione decreases with age