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25,26 The behavior and therapeutic potential of MSCs are tightly regulated by intrinsic and extrinsic factors, including microenvironmental cues, epigenetic modifications, and cytokine signaling, where MSCs release a diverse range of bioactive molecules, including growth factors, cytokines, and extracellular vesicles (EVs)

Conversely, histone deacetylases (HDACs) remove acetyl groups, leading to chromatin condensation and gene repression

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

For instance, the M83 mouse expressing mutant human syn demonstrates that abnormal syn accumulation is sufficient to drive neurodegenerative phenotypes including neuronal hyperactivity and vascular patterning defects, even in the absence of overt systemic inflammation [164, 165]

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