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After thorough examination, depending on the diagnosis, treatment may include topical minoxidil, low-dose oral minoxidil, correction of nutritional deficiencies, anti-androgen therapy in some women, platelet-rich plasma, treatment of dandruff or scalp inflammation, or clinical monitoring when the pattern is self-limiting

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They account for approximately one million lower-limb amputations each year, representing up to 85% of all diabetes-related amputations worldwide 7

The Centers for Disease Control and Prevention (CDC) and other authorities recommend methotrexate be administered only by healthcare professionals familiar with its uses, toxicities, and safety precautions