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For your first cycle, I recommend sticking to a lighter dosing schedule for 2-4 weeks

Therefore, identifying combinatorial treatments that, in association with the SMN-dependent therapies, could delay MNs degeneration by targeting other molecular pathways, such as oxidative stress, apoptosis, mitochondrial dynamics, known to be altered in SMA 10 , may represent a pivotal therapeutic strategy for those patients who currently poorly benefit from Spinraza, Zolgensma or Evrysdi

Data also suggest that 5 mM BHB in the circulation may improve the survival rate of brain cells (26)

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Kaur R, Greeley B, Ciok A, Mehta K, Tsai M, Robertson H, et al