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Asthma diagnosis is confirmed if stepping down treatment results in increased symptoms and excessive variability in FEV1 and/or PEF

Evidence to support direct effects of H1 receptor antagonism on development of NAFLD is scarce however, H1R antagonism was reported to exacerbate high fat diet induced NAFLD in wild-type mice (Raveendran et al., 2014), suggesting a role of this receptor subtype in the pathogenesis of NAFLD

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