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(ii) A manufacturer must submit the rebate reduction extension request at least 60 calendar days before the start of the second consecutive applicable period in which the manufacturer believes the generic Part D rebatable drug is likely to be in shortage to receive consideration for a reduction in the rebate amount owed, if any, in accordance with paragraph (b)(2) of this section

Changing conditions in the inner-city waterfronts over the last half-century gave the possibility of re-integrating water-urban interfaces into public life, particularly through waterfront redevelopment processes

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NF-B regulates many genes in the inflammatory response that can be promoted by proinflammatory stimuli, such as CS and TNF- (Rhee et al., 2007)