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Supporting Information Available The Supporting Information is available free of charge at Experimental procedures and HPLC, NMR, and HRMS characterization data for mitragynine pseudoindoxyl (PDF) This study was supported by UG3 DA048353 and R01 DA047855 grants from the National Institute on Drug Abuse and the University of Florida Clinical and Translational Science Institute, which is supported in part by the NIH National Center for Advancing Translational Sciences under award number UL1TR001427

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After 48 h, flow cytometry was used to assess GFP and NGFR expression