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Because of these effects, any new-onset palpitations in someone with known thyroid disease (or on thyroid medication) should prompt a careful review of thyroid labs and dosing

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37 In vitro studies have demonstrated that methylnaltrexone does not significantly inhibit or induce many CYP450 enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, or CYP3A4 (Table 3)

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