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As defined by Arthur Riggs and colleagues, it is "the study of mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence." [21] The term has also been used, however, to describe processes which have not been demonstrated to be heritable, such as some forms of histone modification

Alqahtani JS

4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency

Plant Physiol 31:205211 Wolucka BA, Van Montagu M (2003) GDP-mannose 30, 50-epimerase forms GDP-l-gulose, a putative intermediate for the novo biosynthesis of vitamin C in plants

Jacquemyn, J., Cascalho, A