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This same transport route is confirmed by the cumulative AUC-time profiles in CSF and plasma, demonstrating a 30 min delay between plasma absorption and CSF uptake of hydroxocobalamin in rats and in a comparative human study

Its a particularly good fit for those with male or female pattern baldness, says Salkey

Sleep changes Less consistently reported

Those most at risk of a Vitamin B12 deficiency include elderly people, those who follow a vegetarian or vegan diet, people who have had intestinal surgery and people with diseases of the gut, such as Crohn's Disease or Celiac Disease

[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment