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Long-term safety and efficacy of subcutaneous tanezumab versus nonsteroidal antiinflammatory drugs for hip or knee osteoarthritis: a randomized trial

Another potential problem of using senolytics is an acceleration of stem cell exhaustion. Without clearance of apoptotic bodies, secondary necrosis could result in the release of proinflammatory, danger-associated molecular patterns, further exacerbating systemic chronic inflammation

Necrosis appears within hours to days after injury and is characterized by neurons that initially appear swollen, and over time assume a shrunken eosinophilic phenotype with pyknotic nuclei (Raghupathi, 2004)

This situation is further aggravated by several other factors, including a lack of a proper drug development pipeline