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To promote the development of natural products in the regulation and treatment of the immune-metabolic network in PAH, future research needs to advance synergistically from three dimensions: mechanism analysis, clinical translation, and technological breakthroughs

This process is typically triggered and regulated by various factors, including redox homeostasis, antioxidant genes, iron ions, energy metabolism, and lipid metabolism [17, 18], all of which collectively facilitate the ferroptosis process

Although the current findings are ambiguous and evidence from clinical trials does not favor the use of Se as a routine treatment option in GD, nor does the use of Se supplementation affect the remission and recurrence rates of GD (16)

Among them, RvE1 exerts multifaceted anti-inflammatory and immunomodulatory effects by binding to ChemR23 (also referred to as LTB4 receptor BLT1)

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