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Hand (NY) 7(2):151156 Chesterton LS, Blagojevic-Bucknall M, Burton C et al (2018) The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomized controlled trial

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Its epidemiology shows marked geographic variation: incidence is highest in North America and Western Europe (920 cases per 100,000 person-years) but is rising rapidly in regions historically considered low risk, including parts of Asia and South America (Hracs et al., 2025

Furthermore, butyrate-related combination therapies show significant potential in mitigating drug resistance and hepatic toxicity, highlighting their clinical promise for treating complex diseases