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Similarly, an increase in the levels of proinflammatory factors also occurs within ferroptotic cells

Furthermore, compared with mature cultures, immature cultures secrete significantly more alanine and aspartate into the medium, indicating that the transamination route is the primary mechanism by which exogenous glutamate is metabolized in these cells

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At the top, thyroxine (T 4 ) converts to triiodothyronine (T 3 ) via DIO1 and DIO2, or to reverse triiodothyronine (rT 3 ) via DIO1 and DIO3

Furthermore, elucidating the interplay between GSH and critical molecular pathways, including mitochondrial function and lipid metabolism, could provide valuable mechanistic insights and help identify more biomarkers predictive of treatment response