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These are mainly the immune response that involves the microglial activation of the pro-inflammatory cytokines, such as interleukins 1 and 6 (IL-1, IL-6), and TNF (Karik et al., 2004), the nitric oxide synthase (NOS) cascade (Gidday et al., 1999) or the activation of certain enzymes, such as stress-activated kinases, cyclooxygenase-2 (COX-2

writingoriginal draft preparation, J.S., L.H., J.F., H.J., J.S