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30 min pretreatment, followed by 24 h AO exposure) dose-dependently inhibits the release of proinflammatory mediators (TNF-, IL-1, NO) induced by AO in primary mouse microglia, suppresses oxidative stress, and restores the antioxidant capacity of cells [5]

Biomedicines (2021) 9:494

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Among adults, the average duration of medication treatment is about 230 days

Specifically, patients experiencing lingering symptoms often exhibit a significant loss of short-chain fatty acid (SCFA)-producing taxa, such as Fecalibacterium prausnitzii, Eubacterium rectale , Akkermansia and Bifidobacterium pseudocatenulatum , which are critical for maintaining the intestinal barrier and regulating systemic inflammation (63, 6769)