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This effect is probably mediated by the MAPK/Erk1/2 pathway, whereby insulin stimulates the hypothalamus to secrete gonadotropin-releasing hormone (GnRH) ( 3.3 Advanced glycation end products AGEs can severely impair sperm function through multiple mechanisms

Conclusion Continued exploration and rational application of TCM hold significant promise for providing more effective and safer treatment options for PD patients

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To induce colitis, all groups except the NC group received 3.0% (w/v) dextran sulfate sodium (DSS) dissolved in sterile drinking water ad libitum for 7 days, while the NC group received sterile drinking water only