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The limited tumor-targeting specificity, inability to transport the sensitizers deeply intratumorally, and the deteriorating tumor microenvironment limit their anti-tumor effectiveness

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These death receptors bear a death domain (DD) that fosters intracellular proteinprotein interactions, which are pivotal in transmitting apoptosis-inducing signals

is a founder at Atavistik Bio and serves on the scientific advisory boards of Atavistik Bio, Agios Pharmaceuticals, Faeth Therapeutics, General Metabolics and Vida Ventures