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KaplanMeier survival analysis revealed a significant difference in the progression-free interval between the two groups (log-rank p = 0.0019), with cats in the high UGCR group showing a shorter time to progression (Figure 5)

Moreover, after the efferocytosis of ACs by macrophages during atherosclerosis, macrophages showed increased -oxidation and mitochondrial respiration in a lipin-1-dependent manner, a phosphatase with a transcriptional co-regulatory activity related to the expression of genes involved in fatty acid transport and lipid metabolism [74, 75]

Antioxidant treatment with vitamin C attenuated rotator cuff degeneration caused by oxidative stress in Sod1-deficient mice

292 Regarding the dual effects of SIRT1 deacetylation on HIF-1, for instance, under aging or hypoxic conditions, decreased SIRT1 expression and activity has been reported to lead to enhanced acetylation of HIF-1 at Lys709, which upregulates profibrotic and proapoptotic genes, ultimately resulting in tubulointerstitial damage characterized by fibrosis and apoptosis, 293 which means that pharmacological activation of SIRT1 to inhibit HIF-1 activity is proposed as a potential therapeutic strategy for mitigating age-related renal injury