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University of Maryland Medical Centre

Intramuscular injection bypasses this entirely, delivering B12 directly into the bloodstream via muscle tissue for near-complete bioavailability making it the gold standard for treating deficiency and supporting optimal B12 levels

Check B12 levels at 3-6 months after starting therapy

For instance, supplements may be effective for peripheral or diabetic neuropathy, but there is less evidence to support pain relief for sciatic nerve damage